"Azithromycin or doxycycline is recommended treatment for NGU. While treatment-failure in M. genitalium positive NGU appears common with doxycycline...The azithromycin failure rate in M. genitalium positive NGU was 28% (15%–45%) in this study and was associated with recurrent urethral symptoms in 8 of 9 cases. Longer course azithromycin ameliorated but did not resolve symptoms or eradicate infection, whereas moxifloxacin resulted in rapid symptom resolution and eradicated infection. Symptom improvement followed by recrudescence has been reported after levofloxacin failure."
Tetracyclines...
Methods: All M genitalium positive patients (34 men and 26 women) attending an STD clinic during a 6 month period were treated with antibiotics. All patients known to be partners of M genitalium positive patients and those who were M genitalium positive, but not initially treated, were treated with azithromycin. Patients with urethritis and/or cervicitis were treated with tetracyclines before their M genitalium status was known.
Results: 10 of 14 women (71%) and 10 of 16 men (63%) treated with tetracyclines were M genitalium positive at follow up, whereas all patients treated with azithromycin (16 men and 20 women) were M genitalium negative, at the 4 week follow up visit.
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